ANTHRANILIC ACID DERIVATIVES AS INHIBITORS OF THE CGMP-PHOSPHODIESTERASE

摘要

Compounds of formula (I) wherein R<1> is hydrogen or halogen; R<2> is electron withdrawing group; R<3> is hydrogen, hydroxy, lower alkoxy, cycloalkyl, substituted or unsubstituted aryl or substituted or unsubstituted, unsaturated heterocycle; A is lower alkylene; R<4> is lower alkoxy, substituted or unsubstituted, saturated or unsaturated heterocycle, substituted or unsubstituted amino, -CH2-R<5>, -CR<6>R<7>R<8> wherein R<6> and R<7> are each independently carboxy, protected carboxy, substituted or unsubstituted carbamoyl, or substituted or unsubstituted lower alkyl, or R<6> and R<7> together with the carbon atom to which they are attached may form substituted or unsubstituted, saturated carbocycle, or substituted or unsubstituted, unsaturated carbocycle, and R<8> is hydrogen, lower alkoxy, or substituted or unsubstituted lower alkyl; provided that when R<4> is -CR<6>R<7>R<8> wherein R<6> and R<7> are each independently substituted or unsubstituted lower alkyl, and R<8> is hydrogen or lower alkyl, or when R<4> is -CH2-R<5>, R<3> should be hydrogen, hydroxy or cycloalkyl.