| 摘要 |
A process of synthesizing a compound of formula 1: wherein P and P' each independently represent H or a protecting group, R1 represents H or C1-4 alkyl, and Hal represents a halogen selected from Cl, Br and I, comprising: reacting a compound of formula 2: wherein P, P' and R1 are as defined above with an N,O-di-C1-4 alkyl hydroxylamine in the presence of a carbodiimide to produce a compound of formula 3: reacting compound 3 with a compound of formula 4: MetCH2SiR2R3R44 wherein Met represents lithium or halomagnesium; R2, R3 and R4 are C1-4 alkyl or C1-4 alkoxy, and the halo portion of halomagnesium is Cl, Br or I, to produce a compound of formula 5: and reacting compound 5 with a halogenating agent to produce a compound of formula 1.
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