摘要 |
The object is to provide a compound having matrixmetalloproteinase-13 inhibitory activity and aglycanase inhibitory activity. Solution A compound of the following formula (I) or a pharmacologically acceptable salt, ester or other derivative thereof: <CHEM> ÇR<1>: H, NHOH; R<2>: H, optionally substituted alkyl, cycloalkyl, a group -AR<6> A: an alkylene which may be optionally interrupted by O, -S(O)m- or -N(R<9>); R<6>: a group (II), (III), (IV) <CHEM> X: O, S, -N(R<10>)-, -C(R<11>)(R<12>)-; Y: O, CO, -S(O)n-, -N(R<10>)-, -C(R<11>)(R<12>)-; R<7>, R<8>: H, alkyl, COOH, optionally subsituted alkyl, etc.; R<9>, R<10>, R<11>, R<12>: H, alkyl, etc.; m, n: 0 to 2 R<3>: H, optionally substituted alkyl, optionally substituted cycloalkyl, optionally substituted alkenyl, optionally substituted alkynyl; R<4>: optionally substituted (hetero)arylene; R<5>: optionally substituted alkyl, optionally substituted (hetero)aryl. |