发明名称 |
WETTABLE MICROCAPSULES HAVING HYDROPHOBIC POLYMER COATED CORES |
摘要 |
This invention concerns wettable microcapsules having hydrophobic polymer coated cores and to processes for their preparation; in particular, to microcapsules with hydrophobic polymer coats that are wettable so that they are suspendible in aqueous medium. The wettable microcapsules can be prepared by applying hydrophobic polymer onto a drug containing core by phase separation from a solvent to provide microcapsules, optionally washing said microcapsules with a solvent in which said microcapsules are substantially insoluble and drying, characterised in that: (a) one or more surfactants is/are incorporated in the solvent at the phase separation step; and/or (b) one or more surfactants is/are incorporated in the solvent used to wash the microcapsules; and/or (c) the microcapsule is coated with one or more surfactants optionally in the presence of a binder.
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申请公布号 |
CA2328080(A1) |
申请公布日期 |
1999.10.21 |
申请号 |
CA19992328080 |
申请日期 |
1999.04.09 |
申请人 |
EURAND INTERNATIONAL S.P.A. |
发明人 |
MAPELLI, LUIGI GIOVANNI;GENTILINI, LEONARDO;DE LUIGI BRUSCHI, STEFANO;CALANCHI, MASSIMO MARIA |
分类号 |
A61J3/07;A61K9/50;A61K47/38;(IPC1-7):A61K9/50 |
主分类号 |
A61J3/07 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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