A graftable animal cell or tissue of a donor species for use in medicine expresses, or is capable of being caused to express, increased amounts of endogenous complement regulatory molecules for preventing activation of complement in a recipient species. Such tissue or organs are useful for xenotransplantation. Porcine complement regulatory proteins CD59, DAF have been sequenced. Also disclosed are methods of inducing in an animal cell or tissue resistance protection against complement attack.
申请公布号
WO9953042(A2)
申请公布日期
1999.10.21
申请号
WO1999GB01085
申请日期
1999.04.08
申请人
UNIVERSITY OF WALES COLLEGE OF MEDICINE;MORGAN, BRYAN, PAUL;RUSHMERE, NEIL, KEVIN;HINCHLIFFE, STEWART, JAMES;VAN DEN BERG, CARMEN, WILMA