发明名称 |
PROCESS FOR PRODUCING N-GLYCYLTYROSINE AND ITS CRYSTAL STRUCTURE |
摘要 |
Provided is a process for efficiently producing N-glycyltyrosine of high purity represented by the following formula: <IMG> a salt thereof, or a solvate thereof, which comprises adding dropwise to an aqueous suspension of tyrosine or a salt thereof 2 equivalents or more of a haloacetyl halide and an aqueous solution of an inorganic base simultaneously in the presence or absence of an organic solvent, and subjecting the resulting N-haloacetyltyrosine to a reaction with an ammonium ion. Also provided are N-glycyl-L-tyrosine dihydrate having the crystal structures showing specific diffraction patterns in X-ray powder diffraction and processes for producing the same which are characterized by comprising crystallizing the dihydrate from an ethanol-water mixed solvent or water.
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申请公布号 |
CA2268586(A1) |
申请公布日期 |
1999.10.14 |
申请号 |
CA19992268586 |
申请日期 |
1999.04.12 |
申请人 |
KYOWA HAKKO KOGYO CO., LTD. |
发明人 |
IMAI, TAKAHIRO;IMAI, EIICHIRO;MIMURA, TAKASHI;OGASA, TAKEHIRO;KASAI, MASAJI |
分类号 |
C07C233/47;C07K5/06;(IPC1-7):C07K5/062;C07K1/02;C07C231/12 |
主分类号 |
C07C233/47 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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