| 摘要 |
Haptens capable of eliciting antibodies which can catalyze chemical reactions, comprising a hapten or a hapten and a suitable carrier molecule are disclosed. In particular, spiro[4.4]nonane containing dipeptide analogs, which mimic both a torsionally-distorted peptide ground state and the transition state for peptide bond hydrolysis, are described, along with methods of their synthesis and their coupling with amino acids of the D-configuration are described. Antibodies which are catalytically active for chemical reactions, in particular, the cleavage or formation of a selected peptide bond, and which are elicited by such antigens are disclosed as well as methods for producing the antibodies and methods for catalyzing the cleavage or formation of a petpide bond in a molecule.
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