| 发明名称 |
Prodrugs of thrombin inhibitors |
| 摘要 |
PCT No. PCT/SE96/01680 Sec. 371 Date Jan. 31, 1997 Sec. 102(e) Date Jan. 31, 1997 PCT Filed Dec. 17, 1996 PCT Pub. No. WO97/23499 PCT Pub. Date Jul. 3, 1997There is provided compounds of formula I,R1O(O)C-CH2-(R)Cgl-Aze-Pab-R2Iwherein R1 and R2 have meanings given in the description, which are useful as prodrugs of inhibitors of trypsin-like proteases, such as thrombin, and in particular in the treatment of conditions where inhibition of thrombin is required (eg thrombosis) or as anticoagulants. |
| 申请公布号 |
US5965692(A) |
申请公布日期 |
1999.10.12 |
| 申请号 |
US19970776231 |
申请日期 |
1997.01.31 |
| 申请人 |
ASTRA AB |
发明人 |
GUSTAFSSON, DAVID;NYSTROEM, JAN-ERIK;SOERENSEN, HENRIK;SELLEN, MIKAEL |
| 分类号 |
A61K38/55;A61K;A61K31/00;A61K38/00;A61K38/05;A61P7/00;A61P7/02;A61P9/10;A61P43/00;C07D487/04;C07D491/04;C07D495/04;C07K;C07K1/02;C07K5/00;C07K5/02;C07K5/06;C07K5/065;C12N9/99;(IPC1-7):A61K38/00;A61K38/06;C07K7/00 |
主分类号 |
A61K38/55 |
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