发明名称 |
Treatment of uterine contractility disorders with a nitric oxide synthase substrate and/or donor, or a nitric oxide inhibitor |
摘要 |
Dysmenorrhea, disfunctional uterine bleeding, preterm labor and postpartum labor in female mammals are treated by inhibiting uterine contractility by administering thereto a nitric oxide synthase substrate, a nitric oxide donor or both, optionally in combination with one or more of a prostaglandin inhibitor, a prostacyclin-mimetic, a progestin, an oxytocin antagonist or a beta -agonist in an amount effective to ameliorate the symptoms thereof; and inadequate menses treated and induction of abortion or stimulation of labor in a pregnant female is achieved by uterine contractility stimulation by administering thereto a nitric oxide inhibitor, either alone or optionally in a combination of progesterone antagonist, an oxytocin or oxytocin analogue antagonist or a prostaglandin.
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申请公布号 |
US5962413(A) |
申请公布日期 |
1999.10.05 |
申请号 |
US19970934739 |
申请日期 |
1997.09.22 |
申请人 |
SCHERING AKTIENGESELLSCHAFT;THE UNIVERSITY OF TEXAS SYSTEM |
发明人 |
GARFIELD, ROBERT E.;CHWALISZ, KRZYSZTOF;BUKOWSKI, RADOSLAW;YALLAMPALLI, CHANDRA |
分类号 |
A61K31/04;A61K31/195;A61K31/295;A61K31/341;A61K31/557;A61K31/565;A61K31/57;A61K31/60;A61K38/11;(IPC1-7):A61K31/155;A61K31/56 |
主分类号 |
A61K31/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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