发明名称 |
A process for the preparation of 4-(Des-dimethylamino)-tetracyclines. |
摘要 |
The present invention refers to a process for the preparation of 4-(desdimethylamino)-tetracyclines, which compounds have a therapeutical application. The starting tetracyclines are treated with a methylating agent and the resulting trimethylammonium salts are reduced by electrolysis in an aqueous solution at acidic pH, in the presence of an adequate electrolyte. A direct electrical current with a potential of 0.5-1.5 volts is applied between two convenient electrodes until the reaction is complete. The 4-(desdimethylamino)-tetracyclines are isolated by extraction with an organic solvent. |
申请公布号 |
ZA9902484(B) |
申请公布日期 |
1999.10.05 |
申请号 |
ZA19990002484 |
申请日期 |
1999.03.31 |
申请人 |
HOVIONE INTER LTD. |
发明人 |
WILLIAM HEGGIE;JOSE GALINDRO;PEDRO SANTOS;LUIS CARVALHO |
分类号 |
A61K31/65;A61K31/00;A61P43/00;C07C;C07C231/00;C07C231/12;C07C235/82;C07C237/26;C25B;C25B3/00;C25B3/04;C25B7/00 |
主分类号 |
A61K31/65 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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