发明名称 |
Polyhydroxy benzoic acid derivatives and their use as neuraminidase inhibitors |
摘要 |
The present invention is directed to compositions of the formula: wherein: R2 is H, or an alkyl group having 1 to 3 carbon atoms and 0 to 2 hydroxyls; R3 is H, or hydroxyl; R4 is H, or forms a hydrolyzable ester or amide with -CO2-; R5 are H, or are taken together to form =NH; and R6 comprises an amine, or a group having 1 to 12 carbon atoms and 1 to 3 amine groups. The invention is also directed to methods of inhibiting the activity of neuraminidase using the compounds of the invention.
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申请公布号 |
US5958973(A) |
申请公布日期 |
1999.09.28 |
申请号 |
US19950478119 |
申请日期 |
1995.06.06 |
申请人 |
GILEAD SCIENCES, INC. |
发明人 |
BISCHOFBERGER, NORBERT W.;KIM, CHOUNG U.;LEW, WILLARD;LIU, HONGTAO;MARTIN, JOHN C.;SWAMINATHAN, SUNDARAMOORTHI;WILLIAMS, MATTHEW A. |
分类号 |
A61K31/195;A61K31/196;(IPC1-7):A61K31/24;A61K31/19;C07C229/34;C07C63/06 |
主分类号 |
A61K31/195 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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