| 摘要 |
The invention relates to the field of receptors, more specifically to those receptors that are located on the surface of the cell. The invention provides an inhibitor or pharmaceutical composition that is capable of inhibiting down-regulation of a cell surface receptor. The invention provides a method to control or up-regulate hormone activity by using inhibitors or reagents that modify down-regulation of a cell surface receptor. The invention further provides a method to control or up-regulate hormone activity wherein ligand-induced receptor uptake and/or degradation by endocytosis of a receptor is inhibited, preferably by inhibiting the ubiquitin/proteasome system. |
