PHOSPHONOCEPHEM DERIVATIVE, ITS PRODUCTION AND USE THEREOF

摘要

PROBLEM TO BE SOLVED: To obtain the subject new compound having a specific cationic group and a phosphonoamino-substituted five-membered cyclic group on a cephem skeleton, having water solubility, excellent antibacterial actions on (methicillin- resistant) Staphylococcus aureus, bacteria belonging to the genus Pseudomonas, or the like, and useful as an antibacterial agent. SOLUTION: A compound of formula I [R<1> is phosphono group or the like; R<2> is H or a binding group through one or more carbon atoms; Q and X are each N or CH; Y is S, O or CH2 ; (n) is 0 or 1; one of R<3> and R<4> is a (substituted) pyridinium and the other is H, a (substituted) hydrocarbon group or the like], its ester or salt thereof. For example, 7β-[2(Z)-ethoximino-2-(5- phophonoamino-1,2,4-thiadiazol-3-yl)acetamido]-3-[4-(1-methyl-4-pyridi nio)-2- thiazolylthio]-3-cephem-4-carboxylate. The compound of formula I is obtained by reacting a compound of formula II with a compound of formula III.