| 发明名称 |
Sequence specific DNA binding by p53 |
| 摘要 |
Specific sequences in the human genome are the sites of strong binding of wild-type p53 protein, but not mutant forms of the protein. These sequences are used diagnostically to detect cells in which the amount of wild-type p53 is diminished. The sequences can also be used to screen for agents which correct for loss of wild-type p53 to DNA in cancer cells.
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| 申请公布号 |
US5955263(A) |
申请公布日期 |
1999.09.21 |
| 申请号 |
US19940299074 |
申请日期 |
1994.09.01 |
| 申请人 |
JOHNS HOPKINS UNIVERSITY;GENZYME CORPORATION |
发明人 |
VOGELSTEIN, BERT;KINZLER, KENNETH W.;SHERMAN, MICHAEL I. |
| 分类号 |
A61B10/00;C07K14/47;C12N15/09;C12P21/08;C12Q1/02;C12Q1/68;G01N33/50;G01N33/53;G01N33/574;G01N33/577;G01N33/68;(IPC1-7):C12Q1/68;G01N33/48;C07H21/02 |
主分类号 |
A61B10/00 |
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