发明名称 |
HEPARIN COFACTOR II-CONTAINING COMPOSITIONS AND METHOD FOR STABILIZING THE SAME |
摘要 |
Stable heparin cofactor II (HCII)-containing compositions. More particularly, HCII-containing compositions containing pH regulating agents as a stabilizer. These HCII-containing compositions are characterized by being adjusted to pH 6 to 12, preferably 6 to 10 and still preferably 6.5 to 10 by the pH regulating agent. HCII-containing compositions containing nonionic surfactant as a stabilizer. In these HCII-containing compositions, a decrease in HCII activity, polymerization of HCII and formation of insoluble matters are inhibited, thus achieving a high stability.
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申请公布号 |
WO9945953(A1) |
申请公布日期 |
1999.09.16 |
申请号 |
WO1999JP01102 |
申请日期 |
1999.03.05 |
申请人 |
YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD.;ASAHARA, NAOMI;GOTO, TAKASHI;OMIZU, AKIMASA;UEMURA, YAHIRO |
发明人 |
ASAHARA, NAOMI;GOTO, TAKASHI;OMIZU, AKIMASA;UEMURA, YAHIRO |
分类号 |
A61K9/00;A61K38/57;A61K47/12;A61P7/02;(IPC1-7):A61K38/57 |
主分类号 |
A61K9/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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