摘要 |
Human EDG-1c polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Human EDG-1c is identified as a selective receptor for sphingosine-1-phosphate ("S-1-P") and for dihydro S-1-P. Also disclosed are methods for discovering agonists and antagonists of the interaction between S-1-P and dihydro S-1-P and their cellular receptor, human EDG-1c, which may have utility in the treatment of several human diseases and disorders, including, but not limited to the treatment of infections such as bacterial, fungal, protozoan and viral infections.
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申请人 |
SMITHKLINE BEECHAM CORPORATION;SB LABORATOIRES PHARMACEUTIQUES;SMITHKLINE BEECHAM PLC;STADEL, PAMELA HF |
发明人 |
BERGSMA, DERK, J.;CHAMBERS, JONATHAN, K.;CHAN, WINNIE;JOHNSON, RANDALL, K.;KHANDOUDI, NASSIRAH;LIVI, GEORGE, P.;ROBERT, PHILLIPPE;STADEL, JEFFREY, M. DI;WILSON, SHELAGH |