发明名称 |
METHODS AND TOOLS FOR IDENTIFYING COMPOUNDS WHICH MODULATE ATHEROSCLEROSIS BY IMPACTING LDL-PROTEOGLYCAN BINDING |
摘要 |
The present invention relates to the study and control of atherosclerosis through the modulation of LDL-proteoglycan binding at Site B (amino acids 33593369) of the apo-B100 protein in LDL. The invention encompasses methods of identifying compounds which modulate LDL-proteoglycan binding, methods of identifying compounds which modulate atherosclerotic lesion formation, and methods of modulating the formation of atherosclerotic lesions. The invention also encompasses mutant apo-B100 proteins and LDL which exhibit reduced proteoglycan binding while maintaining LDL-receptor binding, polynucleotides which encode these apo-B100 proteins, as well as cells and animals which express the mutant apo-B100 proteins. |
申请公布号 |
CA2323056(A1) |
申请公布日期 |
1999.09.16 |
申请号 |
CA19992323056 |
申请日期 |
1999.03.05 |
申请人 |
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA |
发明人 |
INNERARITY, THOMAS LLOYD;BOREN, JAN OLOF SOLVE |
分类号 |
G01N33/92;(IPC1-7):G01N33/556;G01N33/48 |
主分类号 |
G01N33/92 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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