发明名称 |
Methods of inhibiting T cell mediated immune responses with humanized LO-CD2A-specific antibodies |
摘要 |
The present invention relates to a LO-CD2a antibody and methods of using such antibodies or molecules that bind to the same epitope (or a portion thereof) to prevent and inhibit an immune response in human patients, preferably, where the immune response is mediated by the activation and proliferation of T cells or natural killer cells. The administration of an effective amount of the LO-CD2a antibody to a human patient will prevent or inhibit graft rejection, graft versus host disease or autoimmune disease.
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申请公布号 |
US5951983(A) |
申请公布日期 |
1999.09.14 |
申请号 |
US19950477989 |
申请日期 |
1995.06.07 |
申请人 |
UNIVERSITE CATHOLIQUE DE LOUVAIN;BIO TRANSPLANT, INC. |
发明人 |
BAZIN, HERVE;LATINNE, DOMINIQUE;KAPLAN, RUTH;KIEBER-EMMONS, THOMAS;POSTEMA, CHRISTINA E.;WHITE-SCHARF, MARY E. |
分类号 |
A61K38/00;A61P37/06;C07K16/28;(IPC1-7):A61K39/395;C12N5/12;C07H21/04 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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