发明名称 COMPOSITION FOR USE IN TREATING AND PREVENTING INFLAMMATION RELATED DISORDER
摘要 The present invention is related to a use for treating and preventing inflammation related disorder of a composition containing a drug and hyaluronic acid (HA) or HA mixture, whereas the HA or the HA mixture as a delivery vehicle can be a formulation including at least two HAs having different average molecular weights. The composition has been demonstrated to be capable of reducing the therapeutic dose of a drug on the treatment and prevention of inflammation related disorders is acute inflammatory disease, chronic obstructed pulmonary disease, coeliac disease, conjunctivitis, otitis, allergic rhinitis, gingivitis, aphthous ulcer, bronchitis, gastroesophageal reflux disease (GERD), esophagitis, gastritis, enteritis, peptic ulcer, inflammatory bowel disease (IBD), Crohn's Disease, irritable bowel syndrome (IBS), intestinal inflammation or allergy, urethritis, cystitis, vaginitis, proctitis, eosinophilic gastroenteritis, or rheumatoid arthritis.
申请公布号 US2016193343(A1) 申请公布日期 2016.07.07
申请号 US201615068742 申请日期 2016.03.14
申请人 AIHOL CORPORATION 发明人 Lin Shyh-Shyan
分类号 A61K47/36;A61K31/196 主分类号 A61K47/36
代理机构 代理人
主权项 1. A composition for use in treating an inflammation related disorder comprising: a drug being an anti-inflammatory drug or derivatives thereof; a dose of the drug from 250 milligrams (mg) to 1000 mg; and a glycosaminoglycan selected from the group consisting of: (a) a low average molecular weight hyaluronic acid (LMWHA); (b) a high average molecular weight hyaluronic acid (HMWHA); and (c) a hyaluronic acid mixture of LMWHA and HMWHA; wherein the average molecular weight of LMWHA is between 50 kilo Dalton (Da) and 1.5 million Da; wherein the average molecular weight of HMWHA is between 1.5 kilo Da and 5 million Da; wherein the ratio of the LMWHA of the hyaluronic acid mixture by weight is x, and the ratio of the HMWHA by weight is (1-x); when x is 0.2 to 0.8, the average molecular weight of the LMWHA does not exceed 1.5 million Da, the average molecular weight of the HMWHA is between 1.5 million Da and 5 million Da, and the LMWHA and the HMWHA are apart from each other by at least 0.5 million Da.
地址 Las Vegas NV US