发明名称 |
DERIVATIVES OF AZETIDINE AND PYRROLIDINE |
摘要 |
The invention relates to a compound having formula (I) wherein A is an optionally unsaturated 5- or 6-membered ring, which may comprise a heteroatom selected from N, O and S and which may be substituted with oxo or (1-6C)alkyl; R<1>, R<2> and R<3> are independently H, (1-6C)alkyl, (1-6C)alkoxy, (1-6C)alkoxy-(1-6C)alkyl, carbo(1-6C)alkoxy or halogen; X is O or S; and n is 1 or 2; or a pharmaceutically acceptable salt thereof, with the exception of 3-(naphth-1-yl-oxy)-pyrrolidin and 3-(5,6,7,8-tetrahydro-naphth-1-yl-oxy)-pyrrolidin. The compounds of the invention have antidepressant activity and can be used in treating or preventing serotonin-related diseases.
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申请公布号 |
WO9943647(A1) |
申请公布日期 |
1999.09.02 |
申请号 |
WO1998EP01282 |
申请日期 |
1998.02.26 |
申请人 |
AKZO NOBEL N.V.;LEYSEN, DIRK;WIERINGA, JOHANNES, HUBERTUS;BROEKKAMP, CHRISTOPHORUS, LOUIS, EDUARD |
发明人 |
LEYSEN, DIRK;WIERINGA, JOHANNES, HUBERTUS;BROEKKAMP, CHRISTOPHORUS, LOUIS, EDUARD |
分类号 |
C07D205/04;C07D207/12;C07D401/12;C07D409/04;C07D409/12;(IPC1-7):C07D205/04;A61K31/395;A61K31/40 |
主分类号 |
C07D205/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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