DICLAVULANIC ACID SALTS WITH DIAMINO ETHERS AND PROCESS FOR THEIR PREPARATION

摘要

PCT No. PCT/GB95/03039 Sec. 371 Date Dec. 3, 1996 Sec. 102(e) Date Dec. 3, 1996 PCT Filed Dec. 22, 1995 PCT Pub. No. WO96/20199 PCT Pub. Date Jul. 4, 1996A di-clavulanate salt derived from clavulanic acid and a diamino ether of the formula wherein R1 is an alkylene group, optionally having one or more inert substituents: and each of R2 and R3 is a hydrogen atom or an alkyl group, optionally having one or more inert substituents, or R2 and R3 together complete a heterocyclic ring having four to seven carbon atoms, again optionally having one or more inert substituents. A process for preparing the clavulanic acid salt includes the steps of preparing a substantially water free solution of clavulanic acid, or a salt thereof, in an organic solvent which solution is at a maintained temperature of 0 DEG to 15 DEG C. and then reacting the clavulanic acid, or salt thereof, with diamino ether in the organic solvent.