发明名称 |
LOW FLUORESCENCE ASSAY PLATFORMS AND RELATED METHODS FOR DRUG DISCOVERY |
摘要 |
One aspect of the present invention is a multi-well platform for fluorescence measurements, comprising a plurality of wells within a frame, wherein the mufti-well platform has low fluorescence background. Another aspect of the present invention is a system for spectroscopic measurements, comprising reagents for an assay and a multi-well platform for fluorescence measurements. A further aspect of the present invention is a method for detecting the presence of an analyte in a sample contained in a multi-well platform by detecting light emitted from the sample. Another aspect of the present invention is a method from identifying a modulator of a biological process or target in a sample contained in a multiwell platform by detecting light emitted from the sample. Another aspect of the present invention is a composition identified by this method. A further aspect of the present invention is a method to identify a therapeutic. A further aspect of the present invention is a method of testing a therapeutic for therapeutic activity and toxicology by identifying a therapeutic using a method of the present invention and monitoring the toxicology and efficacy of the therapeutic in an in vivo model.
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申请公布号 |
CA2271373(A1) |
申请公布日期 |
1999.08.24 |
申请号 |
CA19992271373 |
申请日期 |
1999.02.24 |
申请人 |
AURORA BIOSCIENCES CORPORATION |
发明人 |
TSIEN, ROGER Y.;STYLLI, HARRY;PHAM, ANDREW A.;HAROOTUNIAN, ALEC TATE;COASSIN, PETER J. |
分类号 |
B01L3/00;B01L9/00;C40B60/14;(IPC1-7):G01N21/62;G01N21/64 |
主分类号 |
B01L3/00 |
代理机构 |
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主权项 |
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