发明名称 |
Crystals of the tyrosine kinase domain of non-insulin receptor tyrosine kinases |
摘要 |
Crystals of the tyrosine kinase domain of cytoplasmic tyrosine kinases and receptor tyrosine kinases that undergo ligand-mediated receptor dimerization are provided. In particular, crystals of a mutant of the tyrosine kinase domain of fibroblast growth factor receptor 1 (FLGK), alone and in complex with a non-hydrolyzable adenosine triphosphate analogue, are provided. Also provided are the high resolution three dimensional structures of crystalline FLGK, both alone and in co-complex with the adenosine triphosphate analogue, as determined by X-ray diffraction.
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申请公布号 |
US5942428(A) |
申请公布日期 |
1999.08.24 |
申请号 |
US19960701191 |
申请日期 |
1996.08.21 |
申请人 |
SUGEN, INC. |
发明人 |
MOHAMMADI, MOOSA;SCHLESSINGER, JOSEPH;HUBBARD, STEVAN R. |
分类号 |
C07K14/71;C12N9/12;G01N33/68;(IPC1-7):C07K14/705 |
主分类号 |
C07K14/71 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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