| 摘要 |
PCT No. PCT/IB96/00670 Sec. 371 Date Apr. 24, 1998 Sec. 102(e) Date Apr. 24, 1998 PCT Filed Jul. 11, 1996 PCT Pub. No. WO97/12868 PCT Pub. Date Apr. 10, 1997This invention provides processes for producing quinolone compounds which comprise cultivating Amycoa sp. FERM BP-4785, and then isolating quinolone compounds from the fermentation broth. The compounds produced by these processes include compounds of formula (I) wherein R1 is H, R2 is (a) and R3 is CH3; R1 is CH3, R2 is (a) and R3 is CH3; or R1 is CH3, R2 is (b) and R3 is CH3; and the like. The present invention also relates to a pharmaceutical composition comprising the same, which is useful in the treatment of diseases, disorders and adverse conditions caused by Helicobacter pylori and is particularly useful in the treatment of gastroduodenal disorders, diseases and adverse conditions caused thereby.
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