| 摘要 |
PROBLEM TO BE SOLVED: To prepare the subject new compound capable of inhibiting apoptosis induced by Fas stimulation, and useful as a therapeutic agent of a neurodegenerative disease such as Alzheimer's disease and Parkinson's disease, amyotrophic lateral sclerosis, acquired immunodeficiency syndrome or the like. SOLUTION: This new compound is the compound of formula I [R<1> and R<2> are each hydroxy, silyloxy, H, an alkyl or the like; R<3> and R<4> are each H, a (substituted) alkyl, formyl or the like; R<5> and R<6> are each H, a (substituted) alkyl, a (substituted) alkenyl or the like; R<7> and R<8> are each hydroxy, H, an alkyl or the like; R<9> and R<10> are each H, a halogen or the like], e.g. a compound of formula II. The compound of formula I is obtained by culturing microorganisms belonging to the genus Paecilomyces preferably at 20-25 deg.C at pH6-8 for several days to several weeks, and separating and purifying the produced compound from the culturing material. The medium is the one containing a carbon source (e.g. glucose), a nitrogen source (e.g. soybean powder) and an inorganic salt (e.g. calcium carbonate). |
