发明名称 1,2,4-triazolo[1,5-c] pyrimidine heterocyclic analogues having antagonistic activity on adenosine A2a receptor
摘要 PCT No. PCT/EP96/02881 Sec. 371 Date Jan. 22, 1998 Sec. 102(e) Date Jan. 22, 1998 PCT Filed Jul. 2, 1996 PCT Pub. No. WO97/05138 PCT Pub. Date Feb. 13, 1997Disclosed are adenosine A2a receptor antagonists of the formula wherein A is pyrazole, imidazole or triazole ring; R is R1 and R2 are independently H, OH, halogen, alkoxy, alkyl, nitro, amino, CN, haloalkyl, haloalkoxy, carboxy or carboxamido; or the OH group together with one of R1 or R2, or R1 and R2 together, form a methylenedioxy group; and n is 0-4; said compounds are useful in the treatment of cardiovascular, central nervous system, and respiratory diseases.
申请公布号 US5935964(A) 申请公布日期 1999.08.10
申请号 US19980006698 申请日期 1998.01.23
申请人 SCHERING CORPORATION 发明人 BARALDI, PIER GIOVANNI;CACCIARI, BARBARA;VIZIANO, MONICA VALERIA ANGELA;DIONISOTTI, SILVIO;ONGINI, ENNIO
分类号 C07D487/14;(IPC1-7):A61K31/505 主分类号 C07D487/14
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