SYNERGISM BETWEEN THYMIDINE KINASE GENE THERAPY AND TOPOISOMERASE I AND TOPOISOMERASE II INHIBITORS

摘要

The invention describes a method in which adenovirus mediated thymidine kinase gene therapy enhances the sensitivity of ovarian cancer cells to topoisomerase inhibitors chemotherapy. This combination demonstrates synergistic properties. The combination is most effective when the gene therapy treatment is administered first, followed by topoisomerase inhibitor chemotherapy.