HUMAN BETA-TRCP PROTEIN

摘要

The invention concerns the human .beta.-TrCP for homing proteins towards pathways degraded by proteasome capable of interacting with the HIV-1 virus Vpu protein, with I?B and .beta.-catenin cell proteins and with the Skp1p ce ll protein, and its peptide fragments and the nucleic acid sequences coding for said proteins and its fragments. The invention also concerns the human .beta .- TrCP protein or its peptide fragments for screening HIV-1 antiviral agents, and antitumoral agents and anti-inflammatory agents, the antitumoral agents, the anti-inflammatory agents and the antibodies directed against said protei n and its peptide fragments.