发明名称 |
Antibody/receptor targeting moiety for enhanced delivery of armed ligand |
摘要 |
A method for intracellular delivery of drugs or other agents for diagnosis and therapy of malignancies or immune-mediated or inflammatory conditions. A targeting moiety of an antibody and the ligand-binding region of a selected cytokine receptor is used. The targeting moiety targets surface antigen on a specific cell population. The targeting moiety is administered to a subject, and then, after a specified interval, therapeutic or diagnostic agents linked to the cognate cytokine are given. The invention provides rapid, efficient internalization of the cytokine receptor antibody/antigen complexes. Targeting of a high-level cell surface antigen with such bispecific fusion molecules substantially increases the number of cytokine receptors over their low background level. |
申请公布号 |
AU2226799(A) |
申请公布日期 |
1999.08.02 |
申请号 |
AU19990022267 |
申请日期 |
1999.01.14 |
申请人 |
CENTER FOR MOLECULAR MEDICINE AND IMMUNOLOGY |
发明人 |
JACK BURTON;DAVID M GOLDENBERG |
分类号 |
A61K38/00;A61K47/48;A61P29/00;A61P35/00;A61P37/02;C07K7/08;C07K14/715;C07K16/30;C07K19/00 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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