TRIAZOLO-PYRIDAZINE DERIVATIVES AS LIGANDS FOR GABA RECEPTORS

摘要

A class of substituted 1,2,4-triazolo[4,3-b]pyridazine derivatives (I), wherein Z represents cyclobutyl, 1-methylcyclopentyl or pyrrolidin-1-yl; R<1> represents pyridin-3-yl or pyridin-3-ylphenyl; and R<2> represents methyl-triazolyl or methyl-pyridinyl, are selective ligands for GABA<1> receptors in particular having high affinity for the alpha 2 and/or alpha 3 subunit thereof, and accordingly of benefit in the treatment and/or prevention of disorders of the central nervous system, including anxiety and convulsions.