发明名称 |
ANTIBODIES AGAINST HUMAN IL-12 |
摘要 |
<p>The present invention relates to p75 heterodimer specific anti-human IL-12 antibodies that are characterized by a higher potency and greater efficacy in neutralizing human IL-12 bioactivity than known heterodimer specific IL-12 monoclonal antibodies. The heterodimer specific antibodies recognize one or more epitopes of the human IL-12 p75 heterodimer, but do not bind to the p40 subunit alone. The heterodimer specific IL-12 antibodies neutralize rhesus monkey IL-12 bioactivity with a potency similar to their potency for neutralizing human IL-12 bioactivity making them useful IL-12 antagonists.</p> |
申请公布号 |
CA2318052(A1) |
申请公布日期 |
1999.07.29 |
申请号 |
CA19992318052 |
申请日期 |
1999.01.15 |
申请人 |
F. HOFFMANN-LA ROCHE AG |
发明人 |
GATELY, MAURICE KENT;PRESKY, DAVID HOWARD |
分类号 |
A61K39/395;A61P1/04;A61P3/10;A61P19/02;A61P25/00;A61P29/00;A61P37/02;A61P37/06;C07K16/24;C12N5/10;C12N5/20;C12P21/08;(IPC1-7):C07K16/24 |
主分类号 |
A61K39/395 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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