| 摘要 |
PROBLEM TO BE SOLVED: To obtain new antibiotics having low toxicity, manifesting antibacterial activity to Gram-positive bacterium, and antitumor activity obtained from strain belonging to genus Actinomadura. SOLUTION: These antibiotics are compounds or salts expressed by the formula (R is H or chlorine atom). Decatromicin A in which R is H, has the following physicochemical properties, Appearance and properties: white powder, an acidic substances; melting point: 223-225 deg.C (decompose); specific rotation [α]D<26> :+2.0 deg. (C 1.30, methanol); molecular formula: C45 H57 ClN2 O10 and the like. Decatromicin B in which R is Cl, has the following physicochemical properties. Appearance and properties: white powder, an acidic substances; melting point: 202-206 deg.C (decompose); specific rotation [α]D<28> : -9.0 deg. (C 1.30, methanol); molecular formula: C45 H56 Cl2 O10 and the like. These antibiotics are produced by culturing the producing microorganism producing these antibiotics belonging to genus Actiomadura, in a nutrient medium, separating and collecting from these culture products. |
