PEPTIDE KETONES, PHARMACEUTICAL COMPOSITION AND METHOD OF INHIBITION OF INTERLEUKIN-1beta PROTEASE ACTIVITY

摘要

FIELD: organic chemistry, medicine, pharmacy. SUBSTANCE: invention relates to peptide ketones of the formula (I) 1beta or their pharmaceutically acceptable salt where - H, halogen atom, lower alkyl, phenyl or benzyl; R2 and R3 - H or lower alkyl; A is D- or L-isomer of amino acid (valine or alanine); Z is R4 or O; n = 0-2, and pharmaceutical compositions on their basis showing the selective inhibition of an enzyme that converts an interleukin-CH2 and can be benefit for treatment of patients with inflammatory, immune diseases and cancer. EFFECT: curative effect of compounds and compositions. 15 cl, 15 ex