ALPHA-AMINOAMIDE DERIVATIVES USEFUL AS ANALGESIC AGENTS

摘要

The use, in the manufacture of a medicament for use as an analgesic, of a compound which is an alpha-aminoamide of formula (I) wherein: A is a -(CH2)m-, -(CH2)n-X- or -(CH2)v-O- group wherein m is an integer of 1 to 4, n is zero or an integer of 1 to 4, X is -S- or -NH-, and v is zero or an integer of 1 to 5; s is 1 or 2; R is a furyl, thienyl, or pyridyl ring of a phenyl ring; R1 is hydrogen or C1-C4 alkyl; one of R2 and R3 is hydrogen and the other is hydrogen or C1-C4 alkyl optionally substituted by hydroxy or phenyl; or R2 and R3 taken together with the carbon atom to which they are linked form a C3-C6 cycloalkyl ring; or R2 and R3 are both methyl; R4 is hydrogen or C1-C4 alkyl ring; or a pharmaceutically acceptable salt thereof.