| 发明名称 |
SYNTHESIS OF COMBRETASTATIN A-4 PRODRUGS AND TRANS-ISOMERS THEREOF |
| 摘要 |
Combretastatin A-4 has been previously selected for pre-clinical development as antineoplastic agents. However, it is essentially insoluble in water. New water soluble derivatives of combretastatin A-4 and its qualified analogs have been discovered and synthesized through a multistage process using other derivatives of combretastatin A-4 as intermediates. These water soluble derivatives are herein denominated as "Combretastatin A-4 Prodrugs".
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| 申请公布号 |
CA2314238(A1) |
申请公布日期 |
1999.07.15 |
| 申请号 |
CA19992314238 |
申请日期 |
1999.01.08 |
| 申请人 |
ARIZONA BOARD OF REGENTS, A BODY CORPORATE, ACTING ON BEHALF OF ARIZONA STATE UNIVERSITY |
发明人 |
PETTIT, GEORGE R.;RHODES, MONTE R. |
| 分类号 |
A61K31/661;A61P35/00;A61P43/00;C07F9/09;C07F9/12;(IPC1-7):C07F9/09 |
主分类号 |
A61K31/661 |
| 代理机构 |
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