| 发明名称 |
COMPOUNDS SUITABLE FOR INHIBITION OF FERNESYL PROTEIN TRANSFERASE |
| 摘要 |
<p>Novel compounds of formula (1.0) are disclosed. Compounds of formula (1.0) are represented by the compounds of formulas (1.4) or (1.5) wherein R<1>, R<3> and R<4> are each independently selected from halo. Also disclosed are methods of inhibiting farnesyl protein transferase and the growth of abnormal cells, such as tumor cells.</p> |
| 申请公布号 |
CZ9900845(A3) |
申请公布日期 |
1999.07.14 |
| 申请号 |
CZ19990000845 |
申请日期 |
1997.09.11 |
| 申请人 |
SCHERING CORPORATION |
发明人 |
TAVERAS ARTHUR G.;MALLAMS ALAN K.;AFONSO ADRIANO;FEMISZEWSKI STACY W.;NJOROGE GEORGE F.;DOLL RONALD J.;LALWANI TARIK;ALVAREZ CARMEN |
| 分类号 |
C07D401/04;A61K31/4545;A61K31/496;A61K31/513;A61K31/5377;A61P35/00;C07D401/12;C07D401/14;C07D405/14;C07D409/14;C07D413/14;C07D417/14;C07D471/04;C07D521/00;(IPC1-7):C07D401/14;A61K31/445;A61K31/44 |
主分类号 |
C07D401/04 |
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