发明名称 |
USE OF IMMUNOSTIMULATORY OLIGONUCLEOTIDES FOR PREVENTING OR REDUCING ANTIGEN-STIMULATED, GRANULOCYTE-MEDIATED INFLAMMATION |
摘要 |
The invention relates to methods for preventing or reducing antigen-stimulated, granulocyte-mediated inflammation in tissue of an antigen-sensitized mammal host by delivering an immunostimulatory oligonucleotide to the host. In addition, methods for using the immunostimulatory oligonucleotides to boost a mammal host's immune responsiveness to a sensitizing antigen (without immunization of the host by the antigen) and shifting the host's immune responsiveness to a Th1 phenotype to achieve various therapeutic ends are provided. Kits for practicing the methods of the invention are also provided.
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申请公布号 |
WO9911275(A9) |
申请公布日期 |
1999.07.08 |
申请号 |
WO1998US18382 |
申请日期 |
1998.09.04 |
申请人 |
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA |
发明人 |
RAY, EYAL |
分类号 |
A61K47/28;A61K31/711;A61K39/35;A61K47/36;A61K47/42;A61K47/44;A61K47/48;A61P11/06;A61P21/00;A61P27/02;A61P27/16;A61P29/00;A61P37/08;(IPC1-7):A61K31/70;A61K39/385 |
主分类号 |
A61K47/28 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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