发明名称 |
DELIVERY OF POLYPEPTIDE-ENCODING PLASMID DNA INTO THE CYTOSOL OF MACROPHAGES BY ATTENUATED SUICIDE BACTERIA |
摘要 |
The invention relates to the introduction of DNA or RNA sequences into a mammalian cell to achieve controlled expression of a polypeptide. It is therefore useful in gene therapy, vaccination, and any therapeutic situation in which a polypeptide should be administered to a host or cells of said host, as well as for the production of polypeptides by mammalian cells, e.g., in culture or in transgenic animals.
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申请公布号 |
CA2317111(A1) |
申请公布日期 |
1999.07.08 |
申请号 |
CA19982317111 |
申请日期 |
1998.12.18 |
申请人 |
SCHERING AKTIENGESELLSCHAFT |
发明人 |
GENTSCHEV, IVAYLO;KAUFMANN, STEFAN;DIETRICH, GUIDO;HESS, JURGEN;GOEBEL, WERNER |
分类号 |
C12N15/09;A61K35/74;A61K39/02;A61K39/112;A61K48/00;A61P37/02;C12N1/21;C12N15/87;(IPC1-7):C12N15/87;A61K39/00;A61K31/70;C12N15/74;C12N15/85 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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