Polipeptideo conjugado em um polipeptídeo e um polímero biocompatível e do fator viii do fator de von willebrand ou um combinação destes e utilização dos mesmos

摘要

The invention relates to a conjugate of factor VIII and a biocompatible polymer, said conjugate obtainable by a process comprising: (a) immobilizing factor VIII by interaction with a group-specific adsorbent carrying anionic-exchange ligands; (b) activating a biocompatible polymer; (c) conjugating the activated biocompatible polymer to external sites of the immobilized factor VIII; and (d) eluting the conjugate from the adsorbent.