D-homo vitamin D3 derivatives

摘要

Compounds of formula I: wherein the dotted carbon-carbon bond in the D-ring is C-C or C=C; C(R,R) is CH2 or C=CH2, R1 is H, F or OH, R2 and R3 are each independently C1-4-alkyl or CF3, or together with the carbon to which they are bound form C3-6-cycloalkyl. are useful in the treatment of vitamin D dependent disorders, such as psoriasis, leukemia; acne and seborrhoic dermatitis; osteoporosis hyperparathyroidism accompanying renal failure; and multiple sclerosis.