| 摘要 |
<p>An electrotransport device with a drug delivery regulating apparatus delivers a proper drug dosage rate over time by adapting to variable skin resistance values. The electrotransport device adapts to a decline in skin resistance over a time that the electrotransport device is used, and to different skin resistances at different skin surface locations. One drug delivery regulating apparatus includes a voltage booster, a serially connectable artificial impedance, and a feedback sensor, which are all connected to a controller. This apparatus outputs a load voltage across two electrodes. The controller monitors the output of the feedback sensor to determine the skin resistance, or a load current, or the load voltage. Based on the monitored value, the load voltage across the electrodes is controlled, so that a targeted drug dose rate is maintained even as the initial skin resistance drops over the period that the electrotransport device is used. The artificial impedance is selectively controlled to prevent overdose where the skin resistance falls below a predetermined resistance, such that a load voltage greater than a supply voltage could result in an overdose.</p> |
