发明名称 THIAZOLE DERIVATIVES
摘要 Compounds of formula I (see fig. I) as well as pharmaceutically usable salts and esters thereof, wherein R1, R2 and R3 have the significance given in claim 1, inhibit the binding of adhesive proteins to t he surface of different types of cell and accordingly influence cell-cell and cellmatrix interactions. They can be used in the form of pharmaceutical preparations for th e control or prevention of neoplasms, tumour metastasing, tumour growth, osteoporosis, Paget's disease, diabetic retinopathy, macular degeneration, reste nosis following vascular intervention, psoriasis, arthritis, fibrosis, kidney failure as well as infection caused by viruses, bacteria or fungi.
申请公布号 CA2257328(A1) 申请公布日期 1999.07.02
申请号 CA19982257328 申请日期 1998.12.30
申请人 F. HOFFMANN-LA ROCHE AG 发明人 WELLER, THOMAS;ALIG, LEO;HILPERT, KURT;EDENHOFER, ALBRECHT
分类号 C07D277/20;A61K31/00;A61K31/425;A61K31/426;A61K31/427;A61K31/44;A61K31/4427;A61K31/4439;A61K38/00;A61P9/00;A61P13/00;A61P13/12;A61P17/00;A61P17/06;A61P19/00;A61P19/02;A61P19/08;A61P19/10;A61P27/00;A61P27/02;A61P31/00;A61P31/04;A61P31/10;A61P31/12;A61P35/00;A61P35/04;A61P43/00;C07C275/26;C07C279/16;C07D277/38;C07D277/48;C07D277/56;C07D417/12;C07K5/117;(IPC1-7):C07D277/56;A61K38/06;C07K5/083;C07D417/14;A61K31/47;A61K31/495;A61K31/535;A61K31/54 主分类号 C07D277/20
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