发明名称 |
THROMBOGENIC POLYPEPTIDE CHIMERAS AND CONJUGATES HAVING ACTIVITY DEPENDENT UPON ASSOCIATION WITH TUMOR VASCULAR ENDOTHELIUM |
摘要 |
Thrombosis-initiating chimeric polypeptides and conjugates, where Figure 1 portrays one of the disclosed examples of the latter, are provided, as well as compositions comprising same and nucleic acid constructs encoding same. At least one component of a chimera or a conjugate is specific for one or more external features of the vascular endothelium of vessels nourishing a tumor and at least one thrombotic component is substantially inactive when not associated with said tumor vascular endothelium, permitting specific destruction of cancer cells of solid tumors in an animal.
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申请公布号 |
CA2318434(A1) |
申请公布日期 |
1999.07.01 |
申请号 |
CA19982318434 |
申请日期 |
1998.12.22 |
申请人 |
NUVAS LLC |
发明人 |
HOUSTON, L.L.;DICKINSON, CRAIG D. |
分类号 |
A61K38/00;A61K47/48;A61K49/00;C07K14/705;C07K14/745;C12N9/68;C12N15/57;(IPC1-7):A61K38/36;C07K19/00;C07K1/10;C07K16/28;C07K16/30;A61K38/37;A61K39/395;C07K16/46;C07K14/475;C12N9/50;A61K38/57;C12N15/62;C12N15/70;C07K14/755;C07K14/81 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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