STRUCTURE AND FUNCTION OF NOVEL LIVING BODY RHYTHM MARKER GENE

摘要

PROBLEM TO BE SOLVED: To provide a novel protein that has a specific amino acid sequence, bonds to the recurrence of the base sequence of AC*AGGC*, relates to the molecular mechanism of diurnal rhythm and is useful as a medicine for jet lag syndrome dissolution as a time-specific marker. SOLUTION: This novel protein has the amino acid sequence given by the formula, or has the amino acid sequences of the formula in which one or more amino acids are deleted, substituted or added. In addition, it has a property to link to the recurrence of the base sequence represented by AC*AGGC* and participates to the molecular mechanism of the circadian rhythm and is useful of the development of narcotic drugs for jet lag syndrome dissolution as a time-specific marker or as a narcotic agent that does not contradict with the biorhythm. This protein is obtained by cloning the cDNA of rat nucleus supraopticus hypothalami as the activity increase of the reporter gene is used as an indication and expressing the cloned gene in the host cells.