| 摘要 |
PCT No. PCT/AU95/00071 Sec. 371 Date Oct. 13, 1995 Sec. 102(e) Date Oct. 13, 1995 PCT Filed Feb. 15, 1995 PCT Pub. No. WO95/22556 PCT Pub. Date Aug. 24, 1995A process for the removal of endotoxin from a biological product such as proteins for therapeutic use, blood plasma fractions, and albumin solutions that contains endotoxins, which comprises contacting said biological product with a cross-linked hydrophilic matrix comprising a copolymer of allyl dextran and N,N'-methylene bisacrylamide under conditions effective to bind endotoxins in said biological product to said matrix, wherein the total amount of endotoxin in said biological product does not exceed the absorptive capacity of said cross-linked hydrophilic matrix, and recovering purified biological product from which endotoxin has been removed as a result of said binding.
|
