INHIBITION OF TUMOR CELLS PROLIFERATION USING RIBOZYMES

摘要

Transient adenovirus-mediated transduction of HER-2/neu ribozymes inhibit HER-2/neu expression in cancer cells. Adenovirus constructs containing the appropriate vectors can be administered parenterally for systemic effect or be administered directly into the tumor and/or into the specific arteries which supply the tumor for purposes of inhibiting tumor growth. Hence, the invention provides a method for inhibiting growth of a malignant tumor by administration of recombinant adenovirus which expresses ribozymes that target PTN mRNA or Her-2/neu in pharmaceutically acceptable carriers.