发明名称 |
NOVEL PEPTIDE, apoEp1.B, COMPOSITIONS AND USES THEREOF |
摘要 |
A peptide derived from apolipoprotein E termed apoEp1.B which includes amino acids 239-252 of the apolipoprotein E is described. The apoEp1.B peptide is a potent immune modulator that acts on a variety of immune cells. Interestingly, apoEp1.B is a dual modulator, capable of both inducing and suppressing an immune response. In particular, apoEp1.B has been shown to induce differentiation of stem cells into dendritic cells, to induce tumor cell differentiation and activation, to inhibit inflammation and to inhibit autoimmune disease. |
申请公布号 |
WO9931227(A2) |
申请公布日期 |
1999.06.24 |
申请号 |
WO1998CA01129 |
申请日期 |
1998.12.11 |
申请人 |
THE UNIVERSITY OF WESTERN ONTARIO;SINGH, BHAGIRATH;RIDER, BEVERLEY |
发明人 |
SINGH, BHAGIRATH;RIDER, BEVERLEY |
分类号 |
A61K38/00;A61K48/00;C07K14/775;C12N15/12 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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