发明名称 |
PROCESS FOR THE PREPARATION OF 6-O-METHYL ERYTHROMYCIN A USING 9-HYDROXY ERYTHROMYCIN DERIVATIVES |
摘要 |
The claimed invention provides a novel method of preparing 6-O-methyl erythromycin A. The process comprises the steps of reducing the 9-keto group of erythromycin A to form a 9-hydroxy erythromycin A, protecting the 9-, 2'-, and/or 4''-hydroxyl groups of erythromycin A, selectively methylating the 6-position of the 9-hydroxy erythromycin A derivative, deprotecting the hydroxyl groups and oxidizing the 9-hydroxyl to afford 6-O-methyl erythromycin A. |
申请公布号 |
CA2615701(A1) |
申请公布日期 |
1999.06.24 |
申请号 |
CA19982615701 |
申请日期 |
1998.11.17 |
申请人 |
ABBOTT LABORATORIES |
发明人 |
RILEY, DAVID A.;LEE, ELAINE C.;KU, YI-YIN;TIEN, JIEN-HEH J. |
分类号 |
C07H17/08;A61K31/7048;A61P31/04 |
主分类号 |
C07H17/08 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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