发明名称 |
Antibodies to a novel tissue inhibitor of metalloproteinases |
摘要 |
The present invention provides a nucleic acid sequence which identifies and encodes a novel tissue inhibitor of metalloproteinases (TIMP-4) which was isolated from cells of human uterus. The invention provides for TIMP-4 antisense molecules and genetically engineered expression vectors and host cells comprising nucleic acid sequence encoding TIMP-4. The invention also provides for purified TIMP-4; antibodies, antagonists and inhibitors which specifically bind TIMP-4; and pharmaceutical compositions and methods of treatment based on TIMP-4, its antagonists and inhibitors. The invention provides for diagnostic assays which utilize diagnostic compositions comprising nucleic acid sequences encoding to TIMP-4, or complements thereof, and antibodies which specifically bind to TIMP-4.
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申请公布号 |
US5914392(A) |
申请公布日期 |
1999.06.22 |
申请号 |
US19980111070 |
申请日期 |
1998.07.07 |
申请人 |
INCYTE PHARMACEUTICALS, INC. |
发明人 |
HAWKINS, PHILLIP R.;MURRY, LYNN E. |
分类号 |
A61K38/00;C07K14/81;C07K16/38;(IPC1-7):C07K16/00;A61K39/395 |
主分类号 |
A61K38/00 |
代理机构 |
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