| 摘要 |
FIELD: organic chemistry, biochemistry, medicine, pharmacy. SUBSTANCE: invention relates to bicyclic tetrahydropyrazole- -pyridines of the formula (I) <EMI ID=0.419 HE=27 WI=36 TI=CHI> where R is C<SB>1-3</SB>-alkyl; X - oxygen atom or two hydrogen atoms; R is C<SB>1-4</SB>-alkyl, indalyl, C<SB>3-7</SB>-cycloalkyl or the group of the formula (II) <EMI ID=0.420 HE=15 WI=54 TI=CHI>; a = 1 or 2; b and c = 0 or 1; R - H, C<SB>1-5</SB>-alkyl, alkoxyl, C<SB>3-6</SB>-cyclo- -alkoxyl, halogen atom, CF<SB>3</SB>, CO<SB>2</SB>R<SB>6</SB>, CONR<SP>6</SP>R<SP>7</SP>, NR<SP>6</SP>R ; R<SP>6</SP>, R - H or C<SB>1-4</SB>-alkyl; Z is SO; Y is C<SB>1-5</SB>-alkylene; R has values indicated for R and methylenecyclopropyl at condition that R and R can not mean simultaneously methyl, or their pharmaceutically acceptable salts and a pharmaceutical composition based on said that inhibit activity of phosphodiesterase of type-IV and production of tumor necrosis factor. EFFECT: enhanced effectiveness of compounds and composition as inhibitors of phosphodiesterase, improved method of treatment. 8 cl, 7 tbl, 39 ex
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